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Image Search Results
Journal: Bioscience Reports
Article Title: Loss of cardiomyocyte-specific adhesion G-protein-coupled receptor G1 (ADGRG1/GPR56) promotes pressure overload-induced heart failure
doi: 10.1042/BSR20240826
Figure Lengend Snippet: ( A ) Survival analysis of CM-ADGRG1-KO versus MHC Cre mice following TAC. * P <0.01, Log-rank (Mantel-Cox) test, n = 11 (CM-ADGRG1-KO; 6 males, 5 females) and 6 (MHC Cre; 4 males, 2 females). ( B ) Gravimetric data was collected from 5-week-post TAC mice and Heart Weight/Tibia Length ratios are indicated. Data are mean ± SEM, * P <0.05, ** P <0.01, ns = not significant, one-way ANOVA with Tukey’s post-hoc test. n = 4 (MHC-Cre Sham; 2 males, 2 females), n = 5 (CM-ADGRG1-KO Sham; 1 males, 4 females), n = 6 (MHC-Cre TAC; 3 males, 3 females), n = 6 (CM-ADGRG1-KO TAC; 2 males, 4 females). ( C ) Wheat germ agglutinin (WGA) staining was performed on cardiac slices from CM-ADGRG1-KO and MHC Cre mice at 5-week post-surgery, with data quantified in histogram. Data are mean ± SEM, ns = not significant, one-way ANOVA with Tukey’s post-hoc test. n = 4 (MHC-Cre Sham; 2 males, 2 females), n = 5 (CM-ADGRG1-KO Sham; 1 male, 4 females), n = 6 (MHC-Cre TAC; 3 males, 3 females), n = 6 (CM-ADGRG1-KO TAC; 2 males, 4 females).
Article Snippet: To assess cardiomyocyte cross-sectional area, hearts were stained overnight at 4°C with
Techniques: Staining